The anniversary was celebrated by a parade and flypast at the base.
Minister for Defence Personnel, Darren Chester, said over the last 75 years RAAF Base East Sale had played a vital role in training next generation air force personnel.
"After World War II, the base became the centre of air force aviation training and this legacy continues today," Minister Chester said.
RAAF Base East Sale is home to the Officer's Training School, No.1 Flying Training School, the School of Air Traffic Control and Central Flying School.
The base is also home to the aerobatic flying team the RAAF Roulettes, which has entertained crowds around Australia with their precision formation flying.
Minister Chester said the Gippsland community was also an important part of the legacy of the base and was grateful for continued support.
"I would like to take this opportunity to thank the local community for its support over the years, as we train the next generation of ADF aviation leaders," Minister Chester said.
"As of early 2019, under the banner of the Air Academy, RAAF Base East Sale will train all elementary officer aircrew for courses in pilot training, air traffic control, air combat officer and mission aircrew."
The base provides a significant part of initial employment training for all officers in aviation roles for the Air Force, as well as for Australian Army and Royal Australian Navy students.